Structure Activity Relationship Study of Polymethoxylated Flavones Targeted Retinal Müller Cells for Prevention of Retinal Diseases

Diabetic retinopathy (DR) is a retinal disease representing one of the main causes vision loss in developed countries. In early stage DR, disruption blood barrier (BRB) observed, and it will lead to vascular permeability visual impairment. Therefore, protection against breakdown BRB may be useful strategy for prevention DR. Matrix metalloproteinases (MMPs) plays an important role degradation extracellular matrix proteins. they attribute increased by degrading junction proteins, such as occuldin cadherin that are maintain complex. Muller cells constitute glial retina involved many functions. They reported MMP-producing retina. this symposium review, I present molecular mechanism MMP expression cells. addition, would like introduce polymethoxylated flavones, nobiletin derivatives isolated from natural resource novel inhibitors, which applicable